Broken blood vessels are the real problem in lifestyle diseases

blood vessels damaged by sugarMost people think cardiovascular disease is all about heart problems and diabetes, is all about sugar problems and the pancreas.

But the heart is a victim of the “real” problem.  And the sugar is compounding the “real” problem. 

So what is the “real” problem ?

Blood vessels are the “real” problem.   The blood vessels have become damaged and this leads to blocks and breaks which can have some nasty consequences.

  • Heart attacks
  • Strokes
  • Blindness
  • Amputation 

Blood vessel troubles begin with too little FAS

A little fancy molecular biology, allowed scientists at Washington University, to create a very special kind of mouse, the FAS less mice (FASTie). 

What makes these mice so special, is they are unable to produce the enzyme, fatty acid synthase (FAS) in their blood vessels.  The mice can produce the enzyme in the rest of their bodies, so everywhere else things are “normal”.

It turns out, the FASTie mice develop broken blood vessels.  The reason for this is because without the FAS enzyme,  they are   unable to produce a type of  “molecular glue”,  which holds another enzyme, nitric oxide synthase (NOS), onto the cells lining the blood vessels.   The process that is defective is  called palmitoylation. 

The absence of the fused NOS becomes problematic, because the cells are not being supplied with sufficient nitric oxide, the chemical produced by the enzyme.  Nitric oxide is a very important messenger so the blood vessels can’t function properly.  They  become leaky when damaged  and the repair process is flawed.

So who cares ?

Insulin instigates FAS shortages

People suffering  from diabetes, both type 1 (too little insulin) and type 2 (too much insulin), typically have very low levels of this enzyme in their blood vessels.

So in diabetics, NOS is not able to bond to the blood vessel cells, resulting in unhealthy blood vessels, that cannot recover very well from damage.  The final cherry on the top, is that high sugar levels,  found in diabetes, cause lots of blood vessel damage. 

Protect those blood vessels

Rein in those insulin levels so that FAS works optimally.

And if the blood vessels are already struggling, protect them from further damage, by keeping those sugar levels within the normal range.

Researchers discover the root cause of blood vessel damage in diabetes.   January 28, 2011 Washington University School of Medicine

Know someone who will find this post useful ? Share it on facebook, linkedin, twitter

Further reading

insulin supervising plaque formation in artery
cholesterol for heart attack rescue
caffeine controlling SHBG
Insulin steers the assembly of killer blood clots Should you feed a heart attack a high fat meal ? A coffee a day keeps diabetes away

The 7 Big Spoons™…. are master switches that turn health on.

balance eicosanoids rein in insulin dial down stress sleep vitamin D microflora think
Balance Eicosanoids Rein in insulin Dial down stress Sleep ! Increase Vit D Culivate microflora Think champion

Sign up for the E-spoons E-zine to get a monthly compilation of the posts from 7 Big Spoons delivered to your inbox.

Hire Dr Sandy from a Spoonful of Science to be the keynote speaker at your next event.

Did you learn something new or do you have a different perspective ? I’d love to hear from you so post me a comment below…..

This entry was posted in Diabetes, Heart disease, Insulin and tagged . Bookmark the permalink. Follow any comments here with the RSS feed for this post. Post a comment or leave a trackback: Trackback URL.

Post a Comment

Your email is never published nor shared. Required fields are marked *

*
*

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>